Enantioselective S−H Insertion Reactions of α‐Carbonyl Sulfoxonium Ylides
Patrícia B. Momo, Alexandria N. Leveille, Elliot H. E. Farrar, Matthew N. Grayson, Anita E. Mattson, Antonio C. B. Burtoloso
Abstract
The first example of enantioselective S-H insertion reactions of sulfoxonium ylides is reported. Under the influence of thiourea catalysis, excellent levels of enantiocontrol (up to 95 % ee) and yields (up to 97 %) are achieved for 31 examples in S-H insertion reactions of aryl thiols and α-carbonyl sulfoxonium ylides.
Topics & Concepts
Enantioselective synthesisThioureaArylChemistryCatalysisInsertion reactionCombinatorial chemistryMedicinal chemistryOrganic chemistryAlkylCyclopropane Reaction MechanismsSynthesis and Catalytic ReactionsCatalytic C–H Functionalization Methods