Rational Design of Novel Anticancer Small-Molecule RNA m6A Demethylase ALKBH5 Inhibitors
Simona Selberg, Neinar Seli, Esko Kankuri, Mati Karelson
Abstract
ranging from 1.38 to 16.5 μM. However, the effect was low or negligible in the case of another leukemia cell line, Jurkat, and the glioblastoma cell line A-172. These results demonstrate the potential of ALKBH5 inhibition as a cancer-cell-type-selective antiproliferative strategy.
Topics & Concepts
Jurkat cellsCell cultureLeukemiaCell growthBiologyCancer cellBiochemistryApoptosisIC50EnzymePharmacophoreChemistryMolecular biologyCancer researchCancerIn vitroT cellImmunologyImmune systemGeneticsRNA modifications and cancerCancer-related gene regulationCancer-related molecular mechanisms research