Description of an In Vitro Platelet Function Analyzer (PFA-100/PFA-200) 30 Years in the Making
Emmanuel J. Favaloro
Abstract
Welcome to another Commentary relating to our celebration of 50 years of publishing for Seminars in Thrombosis and Hemostasis (STH). As previously noted, 2024 marks the 50th birthday of STH, which first published in 1974.[1] A half century of publishing is a landmark worthy of celebration. We started the celebrations in 2022, when we published our first 50th Year Celebratory issue.[2] A second Celebratory issue was published in 2023,[3] and a third compilation was published as the first issue of 2024.[4] All issues were rich with content of a historical nature, as related to the fields of thrombosis and hemostasis. We plan to prepare a 4th and final 50th Year Celebratory compilation later in 2024. In the interim, we plan to publish a separate tribute to the rich history of STH in each issue of STH to publish within 2024. For the first issue of 2024, we republished the first paper ever published in STH, on the molecular structure of fibrinogen,[5] together with an accompanying Commentary from Neerman-Arbez and Casini.[6] The current Commentary accompanies the historical paper entitled "Description of an in vitro platelet function analyzer–PFA-100" republished in the current issue, from the authorship team of Kundu et al, and first published in a Supplementary issue of STH in 1995 ([Fig. 1]),[7] and which was identified as the 3rd most highly cited STH paper of all time.[8]