The chromatin remodeler ISWI acts during <i>Drosophila</i> development to regulate adult sleep
Naihua N. Gong, Leela Chakravarti Dilley, Charlette Williams, Emilia H. Moscato, Milán Szuperák, Qin Wang, Matthew Jensen, Santhosh Girirajan, Tiong Yang Tan, Matthew A. Deardorff, Dong Li, Yuanquan Song, Matthew S. Kayser
Abstract
patient variants fail to rescue sleep. We propose that sleep deficits are a primary phenotype of early developmental origin in NDDs and point toward chromatin remodeling machinery as critical for sleep circuit formation.
Topics & Concepts
Sleep (system call)ChromatinComputer scienceNeuroscienceGeneBiologyGeneticsOperating systemGenetics and Neurodevelopmental DisordersChromosomal and Genetic VariationsGenetics, Aging, and Longevity in Model Organisms