TM9SF1 knockdown decreases inflammation by enhancing autophagy in a mouse model of acute lung injury
Juan Xiao, Xiaofang Shen, Huabo Chen, Lu Ding, Ke Wang, Lihong Zhai, Chun Mao
Abstract
knockout on ALI. Therefore, we discover for the first time the role and mechanism of TM9SF1 in LPS-induced ALI and establish a relationship between TM9SF1 regulated autophagy and ALI progression, which may provide novel targets for the treatment of ALI.
Topics & Concepts
AutophagyKnockout mouseInflammationGene knockdownLungIn vivoDownregulation and upregulationProinflammatory cytokineImmunologyCancer researchMedicineCell biologyChemistryBiologyApoptosisReceptorInternal medicineBiochemistryGeneBiotechnologyAutophagy in Disease and TherapyImmune cells in cancerEpigenetics and DNA Methylation