Visible-Light-Promoted Deoxygenative Alkylation of Quinoxalin-2(1<i>H</i>)-ones with Activated Alcohols
Lili Wang, Pengyuan Yang, Jinwei Yuan, Wei Lian, Xinrong Jin, Sanyu Zhang, Liangru Yang, Dongliang Xing
Abstract
)-ones was developed by using xanthate salts as alcohol-activating groups for radical generation in the presence of tricyclohexylphosphine under visible-light-promoted conditions. The remarkable features of this reaction include a broad substrate scope, excellent functional group tolerance, mild conditions, and simple operation. Moreover, the synthetic utility of this reaction was validated by the success of two-step one-pot reactions, scale-up synthesis, and chemoselective radical monodeoxygenation of diols.
Topics & Concepts
ChemistryAlkylationXanthateAlcoholFunctional groupSubstrate (aquarium)Organic chemistryVisible spectrumReaction conditionsCatalysisCombinatorial chemistryOptoelectronicsOceanographyGeologyPhysicsPolymerRadical Photochemical ReactionsSynthesis and Biological EvaluationOxidative Organic Chemistry Reactions