Structure-based screening combined with computational and biochemical analyses identified the inhibitor targeting the binding of DNA Ligase 1 to UHRF1
Satomi Kori, Yuki Shibahashi, Toru Ekimoto, Atsuya Nishiyama, Sae Yoshimi, Kosuke Yamaguchi, Satoru Nagatoishi, Masateru Ohta, Kouhei Tsumoto, Makoto Nakanishi, Pierre‐Antoine Defossez, Mitsunori Ikeguchi, Kyohei Arita
Topics & Concepts
DNA methylationEpigeneticsChemistryDNA replicationCarcinogenesisDNA ligaseMethylationCell biologyMolecular biologyDNABiologyBiochemistryGeneGene expressionEpigenetics and DNA MethylationCancer-related gene regulationHistone Deacetylase Inhibitors Research