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Structure-based screening combined with computational and biochemical analyses identified the inhibitor targeting the binding of DNA Ligase 1 to UHRF1

Satomi Kori, Yuki Shibahashi, Toru Ekimoto, Atsuya Nishiyama, Sae Yoshimi, Kosuke Yamaguchi, Satoru Nagatoishi, Masateru Ohta, Kouhei Tsumoto, Makoto Nakanishi, Pierre‐Antoine Defossez, Mitsunori Ikeguchi, Kyohei Arita

2021Bioorganic & Medicinal Chemistry23 citationsDOIOpen Access PDF

Topics & Concepts

DNA methylationEpigeneticsChemistryDNA replicationCarcinogenesisDNA ligaseMethylationCell biologyMolecular biologyDNABiologyBiochemistryGeneGene expressionEpigenetics and DNA MethylationCancer-related gene regulationHistone Deacetylase Inhibitors Research
Structure-based screening combined with computational and biochemical analyses identified the inhibitor targeting the binding of DNA Ligase 1 to UHRF1 | Litcius