Function and mechanism of TREM2 in bacterial infection
Zehua Wu, Shiyue Yang, Xiangming Fang, Qiang Shu, Qixing Chen
Abstract
Triggering receptor expressed on myeloid cells 2 (TREM2), which is a lipid sensing and phagocytosis receptor, plays a key role in immunity and inflammation in response to pathogens. Here, we review the function and signaling of TREM2 in microbial binding, engulfment and removal, and describe TREM2-mediated inhibition of inflammation by negatively regulating the Toll-like receptor (TLR) response. We further illustrate the role of TREM2 in restoring organ homeostasis in sepsis and soluble TREM2 (sTREM2) as a diagnostic marker for sepsis-associated encephalopathy (SAE). Finally, we discuss the prospect of TREM2 as an interesting therapeutic target for sepsis.
Topics & Concepts
TREM2SepsisInflammationReceptorPhagocytosisFunction (biology)BiologyImmunologyImmunityCell biologyImmune systemMicrogliaBiochemistryInflammation biomarkers and pathwaysNeuroinflammation and Neurodegeneration MechanismsSepsis Diagnosis and Treatment