LGI1-antibody encephalitis: how to approach this highly treatable dementia mimic in memory and mental health services
Sophie Binks, Adam Al‐Diwani, Adam E. Handel, Bajorek Tomasz, Sanjay Manohar, Masud Husain, Sarosh R. Irani, Ivan Koychev
Abstract
Leucine-rich glioma-inactivated 1-antibody-encephalitis is a treatable and potentially reversible cause of cognitive and psychiatric presentations, and may mimic cognitive decline, rapidly progressive dementia and complex psychosis in older patients. This aetiology is of immediate relevance given the alternative treatment pathway required, compared with other conditions presenting with cognitive deficits.
Topics & Concepts
DementiaPsychosisCognitionEncephalitisEtiologyCognitive declineMedicineLimbic encephalitisPsychiatryPsychologyDiseaseImmunologyPathologyVirusAutoimmune Neurological Disorders and TreatmentsPeripheral Neuropathies and DisordersGenetics and Neurodevelopmental Disorders