Moderate aerobic exercise prevents matrix degradation and death in a mouse model of aortic dissection and aneurysm
Brittany O. Aicher, Jackie Zhang, Selen C. Muratoglu, Rebeca Galisteo, Allison L. Arai, Vicki L. Gray, Brajesh K. Lal, Dudley K. Strickland, Areck A. Ucuzian
Abstract
Moderate aerobic exercise was shown to significantly reduce mortality, extracellular matrix degradation, and thoracic aortic aneurysm and dissection formation associated with lysyl oxidase inhibition in a mouse model. Gene expression suggested a reversal of TGF-β, inflammation, and extracellular matrix remodeling pathway dysregulation, along with augmented elastogenesis with exercise.
Topics & Concepts
Extracellular matrixLysyl oxidaseAortic aneurysmThoracic aortic aneurysmMatrix metalloproteinaseAneurysmAerobic exerciseInflammationElastinDissection (medical)Aortic dissectionMedicineCardiologyInternal medicineChemistrySurgeryPathologyAortaBiochemistryAortic Disease and Treatment ApproachesAortic aneurysm repair treatmentsConnective tissue disorders research