Structural Features of Small Molecule Antioxidants and Strategic Modifications to Improve Potential Bioactivity
Nathan C. Charlton, Maxim Mastyugin, Béla Török, Marianna Török
Abstract
This review surveys the major structural features in various groups of small molecules that are considered to be antioxidants, including natural and synthetic compounds alike. Recent advances in the strategic modification of known small molecule antioxidants are also described. The highlight is placed on changing major physicochemical parameters, including log p, bond dissociation energy, ionization potential, and others which result in improved antioxidant activity.
Topics & Concepts
Small moleculeMoleculeChemistryDissociation (chemistry)Bond-dissociation energyAntioxidantNanotechnologyCombinatorial chemistryComputational chemistryMaterials scienceOrganic chemistryBiochemistryFree Radicals and AntioxidantsAntioxidant Activity and Oxidative StressPhytochemicals and Antioxidant Activities