Tailoring enzyme strategies and functional groups in biosynthetic pathways
Christopher T. Walsh
Abstract
carbons in olefins, electrophilic epoxides have opposite reactivity and often function as "disappearing groups", opened by intramolecular nucleophiles during metabolite maturation. "Thwarted" oxygenases generate radical intermediates that rearrange internally and are not captured oxygenatively.
Topics & Concepts
ElectrophileNucleophileChemistryEnzymeIntramolecular forceFunctional groupCombinatorial chemistrySubstrate (aquarium)Reactivity (psychology)StereochemistryOrganic chemistryCatalysisMedicineGeologyPathologyAlternative medicinePolymerOceanographyMicrobial Natural Products and BiosynthesisMetal-Catalyzed Oxygenation MechanismsEnzyme Catalysis and Immobilization