Clinical Impact of the Epithelial-Mesenchymal Transition in Lung Cancer as a Biomarker Assisting in Therapeutic Decisions
Julien Ancel, Maxime Dewolf, Gaëtan Deslée, Béatrice Nawrocky-Raby, Véronique Dalstein, Christine Gilles, Myriam Polette
Abstract
Lung cancer is one of the most common solid cancers and represents the leading cause of cancer death worldwide. Over the last decade, research on the epithelial-mesenchymal transition (EMT) in lung cancer has gained increasing attention. Here, we review clinical and histological features of non-small-cell lung cancer associated with EMT. We then aimed to establish potential clinical implications of EMT in current therapeutic options, including surgery, radiation, targeted therapy against oncogenic drivers, and immunotherapy.
Topics & Concepts
Lung cancerEpithelial–mesenchymal transitionMedicineCancerBiomarkerRadiation therapyImmunotherapyLungTargeted therapyMesenchymal stem cellOncologyCancer researchPathologyInternal medicineMetastasisBiologyBiochemistryLung Cancer Treatments and MutationsLung Cancer Diagnosis and TreatmentCancer Cells and Metastasis