Fe <sub>3</sub> O <sub>4</sub> @Cellulose Nanofiber Modified by 1,2‐Phenylenediamine Schiff Base/Melamine for Magnetic Solid Phase Extraction of Parabens From Cosmetic Products
Maryam Kashanian, Milad Ghani, Tahere Khezeli, Behrooz Maleki, Pouya Ghamari Kargar
Abstract
ABSTRACT In this work, a new magnetic sorbent, named Fe 3 O 4 @CNF@NNSM, using Fe 3 O 4 nanoparticles modified with cellulose nanofiber (CNF) and 1,2‐phenylenediamine Schiff base/melamine (NNSM) applied to extract methyl, ethyl, propyl, and butyl parabens based on magnetic solid‐phase extraction method followed by high‐performance liquid chromatography‐ultraviolet detection. Characterization of synthesized materials was conducted using Fourier‐transform infrared spectroscopy, field emission‐scanning electron microscopy, X‐ray powder diffraction, transmission electron microscope, energy dispersion spectroscopy, and vibrating sample magnetometry. Factors affecting the extraction efficiency were screened with the Plackett‐Burman design and then analyzed by the Box‐Behnken design. This method exhibited an impressive linear range (0.50–200.00 µg/L R 2 > 0.9921), and detection limits of 0.12–0.15 µg/L for mentioned parabens. The Enrichment factors were obtained from 120 to 175. The practical application of this method was confirmed by evaluating analyte recovery from cosmetic products, achieving over 90% recovery and a relative standard deviation of less than 5.1%, demonstrating the proposed method's commendable accuracy and precision.