ASNEO: Identification of personalized alternative splicing based neoantigens with RNA-seq
Zhanbing Zhang, Chi Zhou, Lihua Tang, Yukang Gong, Zhiting Wei, Gongchen Zhang, Feng Wang, Qi Liu, Jing Yu
Abstract
was applied to two immunotherapy-treated cohorts, we found that alternative splicing based neopeptides generally have a higher immune score than that of somatic neopeptides and alternative splicing based neopeptides could be a marker to predict patient survival pattern. Our identification of alternative splicing derived neopeptides would contribute to a more complete understanding of the tumor immune landscape. Prediction of patient-specific alternative splicing neopeptides has the potential to contribute to the development of personalized cancer vaccines.
Topics & Concepts
RNA-SeqComputational biologyIdentification (biology)RNA splicingAlternative splicingComputer scienceRNABiologyGeneticsGeneExonTranscriptomeGene expressionBotanyRNA and protein synthesis mechanismsGalectins and Cancer BiologyMonoclonal and Polyclonal Antibodies Research