Intranasal administration of recombinant prosaposin attenuates neuronal apoptosis through GPR37/PI3K/Akt/ASK1 pathway in MCAO rats
Jing Yu, Jinlan Li, Nathanael Matei, Wenna Wang, Lihui Tang, Jinwei Pang, Xue Li, Lili Fang, Jiping Tang, John H. Zhang, Min Yan
Topics & Concepts
PI3K/AKT/mTOR pathwayTUNEL assayLY294002Protein kinase BMedicinePharmacologyApoptosisNeuroprotectionSmall interfering RNAImmunologyChemistryTransfectionImmunohistochemistryBiochemistryGeneNeuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology ResearchBarrier Structure and Function Studies