Photochemical organocatalytic enantioselective radical γ-functionalization of α-branched enals
Matteo Balletti, Enrico Marcantonio, Paolo Melchiorre
Abstract
2-based activation of commercially available alkyl halides and blue light irradiation. Concomitantly, a chiral secondary amine catalyst triggers the formation of a dienamine from α-branched enals. This chiral dienamine intercepts the photogenerated radicals with excellent γ-selectivity and good stereocontrol.
Topics & Concepts
ChemistryEnantioselective synthesisRadicalCatalysisSN2 reactionOrganocatalysisNucleophileAmine gas treatingAlkylPhotochemistryHalideSurface modificationSelectivityCombinatorial chemistryOrganic chemistryPhysical chemistryRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques