Population Pharmacokinetics and Pharmacodynamics of Itraconazole for Disseminated Infection Caused by Talaromyces marneffei
Katharine E. Stott, Thuy Le, Thu Nguyen, Sarah Whalley, Jennifer Unsworth, Vo Trieu Ly, Ruwanthi Kolamunnage‐Dona, William Hope
Abstract
= 0.19). This study raises the possibility that the failure of itraconazole to satisfy noninferiority criteria against DAmB for talaromycosis in the IVAP trial was a pharmacokinetic and pharmacodynamic failure.
Topics & Concepts
ItraconazolePharmacodynamicsAmphotericin BPharmacokineticsAntifungalAmphotericin B deoxycholatePopulationMedicinePharmacologyMycosisMicrobiologyBiologyImmunologyEnvironmental healthCaspofunginAntifungal resistance and susceptibilityFungal Infections and StudiesInfectious Diseases and Mycology