APP substrate ectodomain defines amyloid‐β peptide length by restraining γ‐secretase processivity and facilitating product release
Matthias Koch, Thomas Enzlein, Shuyu Chen, Dieter Petit, Sam Lismont, Martin Zacharias, Carsten Hopf, Lucía Chávez‐Gutiérrez
Topics & Concepts
EctodomainAmyloid precursor protein secretaseProteolysisAlpha secretaseAmyloid precursor proteinCell biologyBiologyBiochemistryPeptideBiophysicsEnzymeReceptorAlzheimer's diseaseDiseasePathologyMedicineAlzheimer's disease research and treatmentsProtein Structure and DynamicsSupramolecular Self-Assembly in Materials