Ferritin light chain promotes the reprogramming of glioma immune microenvironment and facilitates glioma progression
Hongjiang Li, Chao Yang, Yanfei Wei, Xueyuan Li, Jiang Wei, Yiran Xu, Lifeng Li, Rongqun Guo, Di Chen, Peng Gao, Haohao Zhang, Hui Qin, Zhenyu Zhang, Xianzhi Liu, Dongming Yan
Abstract
Our study suggested that FTL promoted the development of an immunosuppressive TME by inducing M2 polarization in TAMs, and inhibition of FTL in TAMs reprogrammed the TME and sensitized glioma to anti-PD1 therapy, providing a new strategy for improving the therapeutic effect of anti-PD1.
Topics & Concepts
GliomaTumor microenvironmentCancer researchReprogrammingImmune systemImmunotherapyAngiogenesisPopulationMacrophage polarizationDownregulation and upregulationBiologyCellImmunologyMedicineMacrophageGeneIn vitroEnvironmental healthBiochemistryGeneticsFerroptosis and cancer prognosisImmune cells in cancerExtracellular vesicles in disease