Liposomes co-delivery system of doxorubicin and astragaloside IV co-modified by folate ligand and octa-arginine polypeptide for anti-breast cancer
Guijuan Yue, Chengxiang Wang, Bo Liu, Mangang Wu, Yuangyuan Huang, Yuying Guo, Qun Ma
Abstract
. In nude mice tumor models inoculated with MDA-MB-231/DOX cells, FA-R8-LPs significantly inhibited tumor growth, and overcame doxorubicin resistance, exhibiting excellent antitumor effects. This study demonstrates that liposome-targeted co-delivery systems based on FA and R8 double modifying may provide a new and effective strategy for the treatment of TNBC, which is of great significance for drug combination.
Topics & Concepts
LiposomeDoxorubicinChemistryArginineLigand (biochemistry)Delivery systemPharmacologyBridge (graph theory)Combinatorial chemistryBiochemistryCancer researchMedicineInternal medicineReceptorChemotherapyAmino acidNanoparticle-Based Drug DeliveryPeptidase Inhibition and AnalysisAdvanced biosensing and bioanalysis techniques