Macrophage targeted theranostic strategy for accurate detection and rapid stabilization of the inflamed high-risk plaque
Joon Woo Song, Hyeong Soo Nam, Jae Won Ahn, Hyun-Sang Park, Dong Oh Kang, Hyun Jung Kim, Yeon Hoon Kim, Jeongmoo Han, Jah Yeon Choi, Seung‐Yul Lee, Sunwon Kim, Wang‐Yuhl Oh, Hongki Yoo, Kyeongsoon Park, Jin Won Kim
Abstract
Macrophage targeted PPARγ activator labeled with NIRF rapidly stabilized the inflamed plaques in coronary sized artery, which could be quantitatively assessed using intravascular OCT-NIRF imaging. This novel theranostic approach provides a promising theranostic strategy for high-risk coronary plaques.
Topics & Concepts
InflammationPathogenesisMacrophageVulnerable plaqueMedicineAcute coronary syndromePathologyImmunologyInternal medicineMyocardial infarctionBiologyBiochemistryIn vitroAtherosclerosis and Cardiovascular DiseasesAdipokines, Inflammation, and Metabolic DiseasesProtease and Inhibitor Mechanisms