From bugs to drugs: Bacterial 3-IAA enhances efficacy of chemotherapy in pancreatic cancer
Yongwoo David Seo, Jennifer A. Wargo
Abstract
identified enrichment of indole-3-acetic acid (3-IAA), a tryptophan metabolite produced by gut microbiota, as a predictor of chemotherapy response in pancreatic adenocarcinoma. Recapitulated in mouse models, 3-IAA represents a novel potential therapeutic approach for chemotherapy sensitization.
Topics & Concepts
Pancreatic cancerChemotherapyGemcitabineMedicineAdenocarcinomaInternal medicineOncologyCancer researchCancerPancreatic and Hepatic Oncology ResearchGut microbiota and healthEpigenetics and DNA Methylation