HOXC10 promotes tumour metastasis by regulating the EMT-related gene Slug in ovarian cancer
Yulong Peng, Yuanyuan Li, Yimin Li, Anqi Wu, Lili Fan, Wenli Huang, Chunyan Fu, Zhenghao Deng, Kuansong Wang, Yu Zhang, Guang Shu, Gang Yin
Abstract
, a decrease in hepatic metastasis was seen in xenograft mice harbouring tumours with stable HOXC10 overexpression after miR-222-3p agomir (an overexpression reagent) injection. This study provides the first evidence that HOXC10 promotes ovarian cancer metastasis by regulating the transcription of the EMT-related gene Slug. Moreover, we found that HOXC10 is regulated by miR-222-3p. These data highlight the crucial role of HOXC10 in enhancing ovarian cancer metastasis and may provide a therapeutic target for ovarian cancer.
Topics & Concepts
Ovarian cancerMetastasisSlugCancerHox geneCancer researchMedicineMetastasis Suppressor GeneCancer cellInternal medicineBiologyGeneTranscription factorGeneticsMicroRNA in disease regulationCircular RNAs in diseasesEpigenetics and DNA Methylation