Cooperative Cu/Pd-Catalyzed 1,5-Boroacylation of Cyclopropyl-Substituted Alkylidenecyclopropanes
Hui-Hui Zeng, Yuqing Wang, Yong-Yu He, Xiaoling Zhong, Hongguang Li, Ai‐Jun Ma, Jin‐Bao Peng
Abstract
A Cu/Pd-cocatalyzed 1,5-boroacylation of cyclopropyl-substituted ACPs with B 2 pin 2 and acid chlorides has been developed. Using cyclopropyl-substituted ACPs as the starting material, a broad range of 1,5-boroacylated products with multiple functional groups was prepared in good yields with excellent regio- and stereoselectively. Both aromatic and aliphatic acid chlorides were tolerated in this reaction.
Topics & Concepts
ChemistryCatalysisOrganic chemistryMedicinal chemistryReaction conditionsCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsOrganoboron and organosilicon chemistry