The glymphatic system: a new perspective on brain diseases
Zhao Ding, Xiaodi Fan, Yehao Zhang, Mingjiang Yao, Guangrui Wang, Yilei Dong, Jianxun Liu, Wenting Song
Abstract
The glymphatic system is a brain-wide perivascular pathway driven by aquaporin-4 on the endfeet of astrocytes, which can deliver nutrients and active substances to the brain parenchyma through periarterial cerebrospinal fluid (CSF) influx pathway and remove metabolic wastes through perivenous clearance routes. This paper summarizes the composition, overall fluid flow, solute transport, related diseases, affecting factors, and preclinical research methods of the glymphatic system. In doing so, we aim to provide direction and reference for more relevant researchers in the future.
Topics & Concepts
Glymphatic systemCerebrospinal fluidParenchymaNeuroscienceAquaporin 4MedicinePathologyBiologyCerebrospinal fluid and hydrocephalusTraumatic Brain Injury and Neurovascular DisturbancesNeuroscience of respiration and sleep