Combined inhibition of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase a induces metabolic and signaling reprogramming and enhances lung adenocarcinoma cell killing
Yan Zhou, Yizhen Guo, Maoxin Ran, Wenying Shan, Carlotta Granchi, Elisa Giovannetti, Filippo Minutolo, Godefridus J. Peters, Kin Yip Tam
Topics & Concepts
Lactate dehydrogenase AGlycolysisPyruvate dehydrogenase kinaseCancer researchBiologyProtein kinase BPKM2PI3K/AKT/mTOR pathwayWarburg effectPyruvate dehydrogenase complexCarcinogenesisKinaseCell growthCell biologyCitric acid cycleLactate dehydrogenasePyruvate kinaseBiochemistrySignal transductionMetabolismEnzymeGeneCancer, Hypoxia, and MetabolismATP Synthase and ATPases ResearchMitochondrial Function and Pathology