Interplay of chloride levels and palladium(<scp>ii</scp>)-catalyzed <i>O</i>-deallenylation bioorthogonal uncaging reactions
Gean M. Dal Forno, Eloah Latocheski, Claudio D. Navo, Brunno L. Albuquerque, Albert L. St. John, Frédéric Avenier, Gonzalo Jiménez‐Osés, Josiel B. Domingos
Abstract
as the predominant active species. These insights provide the basis for the design of π-allylpalladium catalysts suited for selective uncaging within specific cellular environments, potentially enhancing targeted therapeutic applications.
Topics & Concepts
Bioorthogonal chemistryCatalysisPalladiumChemistryChlorideCombinatorial chemistryBiochemistryOrganic chemistryClick chemistryClick Chemistry and ApplicationsChemical Synthesis and AnalysisNanoplatforms for cancer theranostics