Evaluation of the Combination of Azithromycin and Naphthoquine in Animal Malaria Models
Zhuchun Bei, Guo‐Fu Li, Jinghua Zhao, Min Zhang, Xiao-Guang Ji, Jingyan Wang
Abstract
Combination therapy using drugs with different mechanisms of action is the current state of the art in antimalarial treatment. However, except for artemisinin-based combination therapies, only a few other combinations are now available. Increasing concern regarding the emergence and spread of artemisinin resistance in Plasmodium falciparum has led to a need for the development of new antimalarials. Moreover, the efficacy of current available chemoprophylaxis is compromised by drug resistance and noncompliance due to intolerable adverse effects or complicated dosing regimens.
Topics & Concepts
ArtemisininMalariaAzithromycinCombination therapyPlasmodium falciparumMedicineDrug resistanceChemoprophylaxisDosingPharmacologyIntensive care medicineDrugAdverse effectBiologyImmunologyAntibioticsInternal medicineMicrobiologyMalaria Research and ControlDrug-Induced Hepatotoxicity and ProtectionComputational Drug Discovery Methods