Bromodomain and extra-terminal motif (BET) inhibition is synthetic lethal with loss of SMAD4 in colorectal cancer cells via restoring the loss of MYC repression
Changxiang Shi, Eun Ju Yang, Yifan Liu, Pui Kei Mou, Guowen Ren, Joong Sup Shim
Topics & Concepts
Synthetic lethalityBromodomainBET inhibitorBiologyCancer researchPsychological repressionGene silencingEctopic expressionTranscription factorRepressorGrowth inhibitionBRD4Cell growthCell cultureGene expressionGeneticsGeneEpigeneticsDNA repairProtein Degradation and InhibitorsCancer-related gene regulationChromatin Remodeling and Cancer