Endogenous modification of the chemoattractant CXCL5 alters receptor usage and enhances its activity toward neutrophils and monocytes
Mieke Metzemaekers, Anneleen Mortier, Alessandro Vacchini, Daiane Boff, Karen Yu, Rik Janssens, Floriana Maria Farina, Samantha Milanesi, Nele Berghmans, Noëmie Pörtner, Jo Van Damme, Marcello Allegretti, Mauro Martins Teixeira, Massimo Locati, Elena Monica Borroni, Flávio A. Amaral, Paul Proost
Abstract
monocytes and human THP-1 monocytes. In vitro and in vivo analyses suggested that CXCL5 targeted monocytes through CXCR1 and CXCR2. Thus, truncation of the N-terminus makes CXCL5 a more potent chemoattractant for both neutrophils and monocytes that acts through CXCR1 and CXCR2.
Topics & Concepts
ChemotaxisCXCL5Cell biologyCXC chemokine receptorsChemokineChemistryReceptorSignal transductionBiologyChemokine receptorBiochemistryChemokine receptors and signalingCell Adhesion Molecules ResearchImmune Response and Inflammation