Reductive hydrobenzylation of terminal alkynes <i>via</i> photoredox and nickel dual catalysis
Xian Zhao, Shengqing Zhu, Feng‐Ling Qing, Lingling Chu
Abstract
Markovnikov-selective migratory insertion of an alkyne into nickel hydride, followed by cross-coupling with benzyl chloride, providing facile access to important 1,1-disubstituted olefins. This reaction enables the generation of nickel hydride by utilizing readily available alkyl amines as the hydrogen source. The mild conditions are compatible with a wide range of aryl and alkyl alkynes as well as chlorides.
Topics & Concepts
Terminal (telecommunication)CatalysisNickelDual (grammatical number)Combinatorial chemistryChemistryPhotoredox catalysisPhotochemistryOrganic chemistryComputer sciencePhotocatalysisTelecommunicationsArtLiteratureCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques