ZIF-8-Derived Nanozyme Loaded with Botanical Fungicides as an Eco-Friendly Nanopesticide for Microenvironment-Enhanced Synergistic Control of Ginseng Seedling Blight
Jing Yu, Jialong He, Y. N. Liu, Jiaheng Li, Chenhao Zhang, Yaling Liu, Rongji Liu, Xu Chen, Kai Dong, Ying‐Ping Wang
Abstract
In this study, we successfully fabricated an eco-friendly nanopesticide with synergistic antifungal efficacy by loading the botanical fungicide osthole (OS) into ZIF-8-derived nanozymes (ZnSA) for microenvironment-enhanced control of ginseng seedling blight. The nanopesticide (OS@ZnSA) exhibited significant photostability and storage stability. Compared with OS technique concentrate, the inhibitory effect on Rhizoctonia solani was increased by 28%. Plant experiments revealed that OS@ZnSA not only promoted the growth of ginseng seedlings but also markedly enhanced the expression of its defense enzymes. Safety evaluation showed that OS@ZnSA had no significant effect on soil microbial community, seed germination, and human immortalized epidermal cells (HaCaT), demonstrating its favorable biosafety profile. Overall, the eco-friendly and microenvironment-enhanced nanopesticides would provide a new perspective for synergistic control of plant disease.