Plasma Glial Fibrillary Acid Protein and Phosphorated Tau 181 Association with Presynaptic Density-Dependent Tau Pathology at <sup>18</sup>F-SynVesT-1 Brain PET Imaging
Junhao Wu, Binyin Li, Jie Wang, Qi Huang, Xing Chen, Zhiwen You, Kun He, Qihao Guo, Songye Li, Yiyun Huang, Tengfei Guo, Wenlin Dai, Wei‐Wei Xiang, Weihuang Chen, Dake Yang, Jun Zhao, Yihui Guan, Fang Xie
Abstract
Plasma phosphorylated tau 181 (p-tau-181) and glial fibrillary acidic protein (GFAP) have potential predictive value for identifying synaptic density as measured using 18 F-SynVesT-1 brain PET; the relationship of plasma p-tau-181 and GFAP with synapse loss might be influenced by tau aggregation rather than amyloid-β deposition or cortical thickness.
Topics & Concepts
Glial fibrillary acidic proteinMedicinePathologyTau proteinAmyloid (mycology)SynapseNeuroscienceAlzheimer's diseaseImmunohistochemistryDiseaseBiologyAlzheimer's disease research and treatmentsNeuroscience and Neuropharmacology ResearchMedical Imaging Techniques and Applications