Single-molecule measurements reveal that PARP1 condenses DNA by loop stabilization
Nicholas A. W. Bell, Philip J. Haynes, Katharina Brunner, Taianá Maia de Oliveira, Maria M. Flocco, Bart W. Hoogenboom, Justin E. Molloy
Abstract
A combination of single-molecule methods shows that PARP1 condenses double-stranded DNA by a loop stabilization mechanism.
Topics & Concepts
ChromatinDNABiophysicsPARP1Poly ADP ribose polymerasePolymeraseBiologyDNA clampChemistryCell biologyMolecular biologyBiochemistryReverse transcriptasePolymerase chain reactionGenePARP inhibition in cancer therapyIntegrated Circuits and Semiconductor Failure AnalysisElectrostatic Discharge in Electronics