Progress and Challenges in the Prevention, Diagnosis, and Management of Cytomegalovirus Infection in Transplantation
Ajit P. Limaye, Tara M. Babu, Michael Boeckh
Abstract
Hosts with compromised or naive immune systems, such as individuals living with HIV/AIDS, transplant recipients, and fetuses, are at the highest risk for complications from cytomegalovirus (CMV) infection. Despite substantial progress in prevention, diagnostics, and treatment, CMV continues to negatively impact both solid-organ transplant (SOT) and hematologic cell transplant (HCT) recipients. In this article, we summarize important developments in the field over the past 10 years and highlight new approaches and remaining challenges to the optimal control of CMV infection and disease in transplant settings.
Topics & Concepts
CytomegalovirusCytomegalovirus infectionImmunologyTransplantationIntensive care medicineMedicineOrgan transplantationCytomegalovirus infectionsDiseaseImmune systemInfection controlHuman immunodeficiency virus (HIV)Human cytomegalovirusViral diseaseHerpesviridaeVirusInternal medicineCytomegalovirus and herpesvirus researchPolyomavirus and related diseasesRenal Transplantation Outcomes and Treatments