Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity <i>in Vivo</i> Mouse Model
Christophe Fromont, Alessio Atzori, Divneet Kaur, Lubna Hashmi, Graziella Greco, Alejandro Cabanillas, Huy V. Nguyen, D. Heulyn Jones, Miguel Garzón, Ana Varela, Brett Stevenson, Greg P. Iacobini, Marc Lenoir, Sundaresan Rajesh, Clare L. Box, Jitendra Kumar, Paige Grant, Vera Novitskaya, Juliet Morgan, F.J. Sorrell, Clara Redondo, Andreas Krämer, C.J. Harris, Brendan Leighton, Steven P. Vickers, Sharon C. Cheetham, Colin Kenyon, Anna M. Grabowska, Michael Overduin, Fedor Berditchevski, Chris J. Weston, Stefan Knapp, Peter M. Fischer, Sam Butterworth
Abstract
validation of CaMK1D as a target for diabetes therapeutics.
Topics & Concepts
In vivoKinaseGene isoformCalmodulinDiabetes mellitusPharmacologyChemistryInsulinInsulin sensitivityGeneBiochemistryInsulin resistanceEndocrinologyEnzymeBiologyGeneticsMetabolism, Diabetes, and CancerProtein Kinase Regulation and GTPase SignalingAdipose Tissue and Metabolism