Challenges of CAR- and TCR-T cell–based therapy for chronic infections
Antonio Bertoletti, Anthony T. Tan
Abstract
While therapy with T cells engineered with a chimeric antigen receptor (CAR) or a classical T cell receptor (TCR) is revolutionizing cancer treatment, its adoption in infectious diseases has been met with considerable resistance. Can we find its value for the cure of infections?
Topics & Concepts
T-cell receptorChimeric antigen receptorT cellReceptorImmunologyMedicineAntigenCancer researchVirologyImmune systemInternal medicineCAR-T cell therapy researchImmune Cell Function and InteractionT-cell and B-cell Immunology