Role and Therapeutic Targeting of SDF-1α/CXCR4 Axis in Multiple Myeloma
Shigeki Ito, Tsuyoshi Sato, Takahiro Maeta
Abstract
The C-X-C chemokine receptor type 4 (CXCR4) is a pleiotropic chemokine receptor that is expressed in not only normal hematopoietic cells but also multiple myeloma cells. Its ligand, stromal cell-derived factor 1α (SDF-1α) is produced in the bone marrow microenvironment. The SDF-1α/CXCR4 axis plays a pivotal role in the major physiological processes associated with tumor proliferation, survival, invasion, dissemination, and drug resistance in myeloma cells. This review summarizes the pleiotropic role of the SDF-1α/CXCR4 axis in multiple myeloma and discusses the future perspective in the SDF-1α/CXCR4 axis-targeted therapies in multiple myeloma.
Topics & Concepts
CXCR4Stromal cellMultiple myelomaCancer researchChemokine receptorChemokineBone marrowStromal cell-derived factor 1HaematopoiesisMedicineReceptorBiologyImmunologyStem cellCell biologyInternal medicineMultiple Myeloma Research and TreatmentsChemokine receptors and signalingProtein Degradation and Inhibitors