Erythroid precursors and progenitors suppress adaptive immunity and get invaded by SARS-CoV-2
Shima Shahbaz, Lai Xu, Mohammed Osman, Wendy Sligl, Justin Shields, Michael Joyce, D. Lorne Tyrrell, Olaide Oyegbami, Shokrollah Elahi
Abstract
cells, co-express ACE2, TMPRSS2, CD147, and CD26, and these can be infected with SARS-CoV-2. In turn, pre-treatment of erythroid cells with dexamethasone significantly diminished ACE2/TMPRSS2 expression and subsequently reduced their infectivity with SARS-CoV-2. This provides a novel insight into the impact of SARS-CoV-2 on erythropoiesis and hypoxia seen in COVID-19 patients.
Topics & Concepts
BiologyErythropoiesisProgenitor cellInfectivityImmunologyHypoxia (environmental)Transferrin receptorVirologyVirusCell biologyCellAnemiaStem cellInternal medicineGeneticsOxygenMedicineChemistryOrganic chemistryErythrocyte Function and PathophysiologyCOVID-19 Clinical Research StudiesPhagocytosis and Immune Regulation