Integrated analysis reveals the molecular features of fibrosis in triple-negative breast cancer
Jia-Han Ding, Yi Xiao, Shen Zhao, Ying Xu, Yu-Ling Xiao, Zhi‐Ming Shao, Yi‐Zhou Jiang, Gen‐Hong Di
Abstract
) as genomic hallmarks of tumors with high fibrosis. Transcriptome analysis revealed the transforming growth factor-beta pathway and hypoxia pathway were key pro-oncogenic pathways in tumors with high fibrosis. Moreover, we systematically evaluate the relationship between fibrosis and different kinds of immune and stromal cells. Tumors with high fibrosis were characterized by an immunosuppressive tumor microenvironment with limited immune cell infiltration and increased fibroblasts. This study proposes new insight into the genomic and transcriptomic alterations potentially driving fibrosis. Moreover, fibrosis is related to an immunosuppressive tumor microenvironment that contributes to the poor prognosis.