Photoredox-Mediated Synthesis of Functionalized Sulfoxides from Terminal Alkynes
Jaswant Kumar, Ajaz Ahmad, Masood Ahmad Rizvi, Majid Ahmed Ganie, Chhavi Khajuria, Bhahwal Ali Shah
Abstract
A photoredox-mediated protocol for the synthesis of α-alkoxy-β-ketosulfoxides and α,β-dialkoxysulfoxides using alkynes, thiol, and alcohols is reported. This work presents a rare single-step synthesis of α-substituted sulfoxides, involving tandem introduction of a thiol and alcohol as a key enabling advancement. Furthermore, the method can be easily employed to access vinyl sulfoxides and β-ketosulfoxides.
Topics & Concepts
ChemistryTandemThiolCombinatorial chemistryPhotoredox catalysisAlcoholAlkoxy groupTerminal (telecommunication)Organic chemistryCatalysisAlkylPhotocatalysisComputer scienceTelecommunicationsMaterials scienceComposite materialSulfur-Based Synthesis TechniquesChemical Synthesis and ReactionsRadical Photochemical Reactions