Downregulation of CYP1A2, CYP2B6, and CYP3A4 in Human Hepatocytes by Prolyl Hydroxylase Domain 2 Inhibitors via Hypoxia-Inducible Factor-α Stabilization
Hiroki Takano, Jun‐ichi Yamaguchi, Sota Kato, Makoto Hamada, Mika Tada, Hiromi Endo
Topics & Concepts
Pregnane X receptorDownregulation and upregulationConstitutive androstane receptorAryl hydrocarbon receptor nuclear translocatorCYP3A4Retinoid X receptorAryl hydrocarbon receptorCYP1A2CYP2B6Nuclear receptorHypoxia-inducible factorsBiologyCytochrome P450ReceptorTranscription factorChemistryEndocrinologyBiochemistryMetabolismGeneCancer, Hypoxia, and MetabolismEicosanoids and Hypertension PharmacologyHigh Altitude and Hypoxia