Design, synthesis and biological evaluation of harmine derivatives as potent GSK-3β/DYRK1A dual inhibitors for the treatment of Alzheimer's disease
Wenwu Liu, Xin Liu, Liting Tian, Yaping Gao, Wenjie Liu, Huanhua Chen, Xiaowen Jiang, Zihua Xu, Huaiwei Ding, Qingchun Zhao
Topics & Concepts
HarmineDYRK1AChemistryGSK-3HyperphosphorylationPharmacologyBiochemistryPhosphorylationBiologyCholinesterase and Neurodegenerative DiseasesSynthesis and bioactivity of alkaloidsSynthesis and Reactivity of Heterocycles