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Design, synthesis and biological evaluation of harmine derivatives as potent GSK-3β/DYRK1A dual inhibitors for the treatment of Alzheimer's disease

Wenwu Liu, Xin Liu, Liting Tian, Yaping Gao, Wenjie Liu, Huanhua Chen, Xiaowen Jiang, Zihua Xu, Huaiwei Ding, Qingchun Zhao

2021European Journal of Medicinal Chemistry82 citationsDOIOpen Access PDF

Topics & Concepts

HarmineDYRK1AChemistryGSK-3HyperphosphorylationPharmacologyBiochemistryPhosphorylationBiologyCholinesterase and Neurodegenerative DiseasesSynthesis and bioactivity of alkaloidsSynthesis and Reactivity of Heterocycles
Design, synthesis and biological evaluation of harmine derivatives as potent GSK-3β/DYRK1A dual inhibitors for the treatment of Alzheimer's disease | Litcius