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Allosteric activation of Hsp70 reduces mutant huntingtin levels, the clustering of N-terminal fragments, and their nuclear accumulation

Brígida R. Pinho, Liliana M. Almeida, Michael R. Duchen, Jorge M.A. Oliveira

2021Life Sciences14 citationsDOIOpen Access PDF

Topics & Concepts

HuntingtinProteostasisHsp70Huntingtin ProteinCell biologyMG132BiologyChaperone (clinical)Protein degradationImmunoprecipitationProtein aggregationProteasomeHSF1BiochemistryMutantHeat shock proteinChemistryProteasome inhibitorGenePathologyMedicineGenetic Neurodegenerative DiseasesHeat shock proteins researchFibromyalgia and Chronic Fatigue Syndrome Research
Allosteric activation of Hsp70 reduces mutant huntingtin levels, the clustering of N-terminal fragments, and their nuclear accumulation | Litcius