Ultra-small quercetin-based nanotherapeutics ameliorate acute liver failure by combatting inflammation/cellular senescence cycle
Yali Feng, Xiaoli Zhang, Juan Li, Shan Fu, Weicheng Xu, Jinfeng Liu, Yuan Yang, Tianyan Chen, Yingren Zhao, Dongmin Li, Mingzhen Zhang, Yingli He
Abstract
In summary, our study characterizes QFN as a potent ROS-scavenging modulator that exhibits both anti-inflammatory and anti-senescent properties, effectively disrupting the detrimental feedback loop between inflammation and cellular senescence. QFN holds considerable potential as a therapeutic agent for the treatment of ALF and other pathologies associated with inflammation and aging.
Topics & Concepts
SenescenceInflammationCellular senescenceChemistryCancer researchCell biologyBiologyImmunologyBiochemistryPhenotypeGeneCurcumin's Biomedical ApplicationsTryptophan and brain disordersAdvanced Nanomaterials in Catalysis