Synthesis, antiproliferative and antitrypanosomal activities, and DNA binding of novel 6-amidino-2-arylbenzothiazoles
Livio Racanè, Valentina Rep, Sandra Kraljević Pavelić, Petra Grbčić, Iva Zonjić, Marijana Raðić Stojković, Martin C. Taylor, John M. Kelly, Silvana Raić‐Malić
Abstract
= 0.12 µM). DNA binding assays showed a non-covalent interaction of 6-amidinobenzothiazole ligands, indicating both minor groove binding and intercalation modes of DNA interaction. Our findings encourage further development of novel structurally related 6-amidino-2-arylbenzothiazoles to obtain more selective anticancer and anti-HAT agents.
Topics & Concepts
ChemistryDNAStereochemistryAmidineCombinatorial chemistryBiochemistrySynthesis and biological activitySynthesis and Biological EvaluationQuinazolinone synthesis and applications