SNHG1 knockdown upregulates miR-376a and downregulates FOXK1/Snail axis to prevent tumor growth and metastasis in HCC
Fanzhi Meng, Jinghua Liu, Tao Lu, Lanlan Zang, Jing Wang, Qiang He, Aijin Zhou
Abstract
by upregulating miR-376a and downregulating FOXK1 and Snail. SNHG1 knockdown exerts anti-tumor activity in HCC, suggesting a therapeutic target.
Topics & Concepts
Gene knockdownSmall nucleolar RNAmicroRNADownregulation and upregulationLong non-coding RNACancer researchBiologySnailMetastasisGeneCancerGeneticsEcologyCancer-related molecular mechanisms researchMicroRNA in disease regulationRNA Research and Splicing