Synthesis and discovery of mitochondria-targeting oleanolic acid derivatives for potential PI3K inhibition
Yi Li, Qingqing Zeng, Rui Wang, Bo Wang, Ruofan Chen, Na Wang, Yiru Lu, Fangwen Shi, Wim Dehaen, Qiyong Huai
Topics & Concepts
Oleanolic acidCytotoxicityApoptosisPI3K/AKT/mTOR pathwayA549 cellCancer cellChemistryProtein kinase BReactive oxygen speciesMitochondrionBiochemistryIn vitroBiologyCancerMedicineGeneticsPathologyAlternative medicineNatural product bioactivities and synthesisATP Synthase and ATPases ResearchBioactive Compounds and Antitumor Agents