Photoinduced Remote C(sp<sup>3</sup>)−H Phosphonylation of Amides
Jian Wang, Yuchen Zhang, Lin Zhu, Xiao‐Song Xue, Chaozhong Li
Abstract
Abstract The present study reports an unprecedented protocol for the phosphonylation of unactivated C(sp 3 )−H bonds. By utilizing 1 mol % 4DPAIPN (1,2,3,5‐tetrakis(diphenylamino)‐4,6‐dicyanobenzene) as the catalyst, satisfactory yields of γ‐phosphonylated amides are obtained through a visible‐light‐induced reaction between N ‐((4‐cyanobenzoyl)oxy)alkanamides and 9‐fluorenyl o ‐phenylene phosphite at room temperature. This protocol demonstrates broad substrate scope and wide functional group compatibility.
Topics & Concepts
ChemistryPhysicsRadical Photochemical ReactionsSulfur-Based Synthesis TechniquesAdvanced Synthetic Organic Chemistry